Norepinephrine is the neurotransmitter of the sympathetic division of the autonomic nervous system (see pp. The adrenomedullary cells synthesize and secrete epinephrine and-to a lesser extent-norepinephrine. 261) and migrate into the center of the adrenal cortex, which is derived from the mesoderm. The cells of the medulla, termed chromaffin cells because the catecholamines that they contain stain avidly with chromium salts, derive from neural crest cells (see p. The adrenal medulla is similar in many ways. On page 978, we describe cells of the hypothalamus as neuroendocrine because they are part of the CNS and appear anatomically as neural tissue, yet they release peptide hormones (e.g., CRH) into the blood that act downstream on the pituitary-a classic endocrine function. The adrenal medulla bridges the endocrine and sympathetic nervous systems Medical Physiology, 3rd Edition The Adrenal Medulla
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